Institute for Immunology and Informatics (iCubed)

The Institute for Immunology and Informatics, along with the URI Biotechnology Center, occupies approximately 7,200 square feet of laboratory space, located at the Feinstein Providence Campus.

iCubed Labs

Vaccine and Immunotherapeutic Research Laboratory (VIRL)

The Vaccine and Immunotherapeutic Research Laboratory is a mixed-use space consisting of a 1,200-square-foot wet lab and a 400-square-foot computer/bioinformatics suite.

VIRL Faculty:

Annie De Groot, M.D., Research Professor

Lenny Moise, Ph.D., Associate Research Professor

Cell Analysis and Sorting Core Lab

This Core provides flow cytometry and automated cell sorting services. Flow cytometry services are available using either a 4-laser, 12-parameter LSR II analyzer or an automated 3-laser, 8-color MACSQuant-10 analyzer. Cell sorting services are available using the AutoMACS platform housed in a class IIA biosafety cabinet.

Laboratory of Viral Immunity and Pathogenesis (LVIP)

The LVIP is a biosafety level 2 laboratory focused on the study of host-virus interactions, with an emphasis on emerging and neglected infectious diseases and global health.

LVIP Faculty:

Anuja Mathew, Ph.D., Associate Research Professor

Carey Medin, Ph.D., Assistant Research Professor

Barbara Lohman-Payne, Ph.D., Associate Research Professor

Alan Rothman, M.D., Research Professor

Anon Srikiatkhachorn, M.D., Associate Research Professor

URI Biotechnology Manufacturing/Cytopathology Labs
  • Protein Purification Lab
  • Industry Training and Research Lab
  • Tissue Culture Lab
  • Cytopathology Research and Teaching Lab

iCubed Equipment

Cell culture
  • Class IIA biosafety cabinets (5)
  • CO2incubators (5; one equipped with refrigeration for 28°C culture)
  • Refrigerated centrifuges (2)
  • Inverted microscope
  • Nexcelom Cellometer automated cell counters (2- T4, Mini)
Flow Cytometry and Immunoassays
  • BD LSRII flow cytometer with 4 lasers
  • Miltenyi MACSQuant-10 flow cytometer
  • CTL Analyzer for cell spot imaging and capture
  • Envision multilabel plate reader (includes filters for fluorescence, luminescence, and AlphaScreen)
  • Liquid nitrogen storage tanks (7; combined capacity >100,000 vials)
  • Ultralow temperature freezers (5; combined capacity >100,000 vials)
  • EVOSfl fluorescence microscope (includes GFP, RFP, DAPI, and Cy5 cubes, 100× oil immersion objective)
  • BioTek Cytation3 cell imaging plate reader with CO2 incubation chamber
  • Confocal microscope
Molecular Biology
  • Bacterial incubator
  • Eppendorf 5810R high speed centrifuge
  • Lab Companion shaking incubator
  • Electrophoresis equipment
  • Nanodrop spectrophotometer
  • Bio-Rad UVM spectrophotometer
  • AKTA Avant 25 FPLC
  • Thermo Fisher Speed Vac Evaporator
  • PCR hood
  • QIAcube (automated nucleic acid isolation)
  • QIAgility (liquid handler/automated PCR assay setup)
  • Bio-Rad dual 48-well PCR machine (2)
  • Bio-Rad CFX96 real-time PCR machine
  • Bio-Rad Chemi-Doc XRS imager
  • MakerBot 3-D printer
  • Miltenyi AutoMacs cell isolation unit
  • Ultracentrifuge
  • Dolomite microfluidics droplet generator with high speed camera
  • Agilent 2100 Bioanalyzer


  • April 15, 2016

    ISV & Vaccine Renaissance Conference – CALL FOR ABSTRACTS!

    The 2016 ISV Annual Congress in collaboration with Vaccine Renaissance X and DNA Vaccine will be held in Boston, Massachusetts, United States on Oct. 2-4, 2016.    Registration abstract is opening soon! The planning committee encourages you to submit an abstract for consideration! Abstract Submission Deadline: June 24th Abstract Decision Deadline: July 15th   http://www.isvcongress.org/
  • March 11, 2016

    10th Annual Vaccine Renaissance Save the Date Postcard

    CLICK HERE to see the save the date postcard for 2016 ISV Conference
  • February 19, 2016

    iCubed Team Members Making Moves

    This past week at iCubed, Dr. Barbara Lohman Payne received a new title of Associate Research Professor. Barbara joined iCubed and URI as a Research Assistant Professor in 2013, with the Laboratory of Viral Immunity and Pathogenesis. Dr. Lohman-Payne’s area of research is viral immunopathology, with special interest in the impact of HIV exposure in ...