H Pylori

H pylori

Helicobacter pylori has been an almost universal constituent of the human microbiome throughout the history of humankind. H. pylori induces a chronic gastric inflammatory response and promotes the development of gastric carcinoma, lymphoma and peptic ulcer disease in a subset of the H. pylori-colonized population. However, its recent disappearance from human populations in the developed world has coincided with the epidemic emergence of allergic asthma, inflammatory bowel disease and some other extra-gastric inflammatory states. Recent animal studies demonstrated that the acquisition of H. pylori infection early in life may reprogram mucosal and systemic immunity in the direction of increased regulatory T cell function and reduced chronic inflammation outside the stomach. We are interested in understanding human immune mechanisms enabling H. pylori to persist long-term in the human stomach while inhibiting inflammation elsewhere. This knowledge may help lead to better understanding of H. pylori’s paradoxical anti-inflammatory role outside the stomach and provide new insights for rational vaccine design against a persistent, but sometimes beneficial, infection.


  • April 15, 2016

    ISV & Vaccine Renaissance Conference – CALL FOR ABSTRACTS!

    The 2016 ISV Annual Congress in collaboration with Vaccine Renaissance X and DNA Vaccine will be held in Boston, Massachusetts, United States on Oct. 2-4, 2016.    Registration abstract is opening soon! The planning committee encourages you to submit an abstract for consideration! Abstract Submission Deadline: June 24th Abstract Decision Deadline: July 15th   http://www.isvcongress.org/
  • March 11, 2016

    10th Annual Vaccine Renaissance Save the Date Postcard

    CLICK HERE to see the save the date postcard for 2016 ISV Conference
  • February 19, 2016

    iCubed Team Members Making Moves

    This past week at iCubed, Dr. Barbara Lohman Payne received a new title of Associate Research Professor. Barbara joined iCubed and URI as a Research Assistant Professor in 2013, with the Laboratory of Viral Immunity and Pathogenesis. Dr. Lohman-Payne’s area of research is viral immunopathology, with special interest in the impact of HIV exposure in ...