Anne S. De Groot, M.D., Director and Research Professor
- Research Professor, iCubed / CELS
- Director, iCubed
- CEO/CSO EpiVax Inc.
- Founder/Scientific Director GAIA Vaccine Foundation
- Volunteer Director Clínica Esperanza /Hope Clinic
Dr. De Groot earned a BA from Smith College in 1978 and her M.D. from Pritzker School of Medicine at the University of Chicago in 1983. She trained in internal medicine at New England Medical Center 1986 followed by training in immunoinformatics and vaccine research under Russell Howard (NIAID Laboratory of Parasitic Diseases) Jay Berzofsky (National Cancer Institute) at the NIH 1989. She returned to NEMC for clinical training in infectious disease in 1991. She was board certified in Internal Medicine in 1986 and in Infectious Disease in 1991. In 1998 Dr. De Groot joined the faculty of Brown University Medical School, where she opened the TB/HIV Research Laboratory. Here she designed the EpiMatrix algorithm with the assistance of Gabe Meister, Bill Jesdale and Bill Martin. She founded EpiVax, Inc. in 1998 and licensed the EpiMatrix technology. In 2009, she was invited to join URI, and establish the Institute for Immunology and Informatics.
Alan L. Rothman, M.D., Head of LVIP and Research Professor
- Research Professor, iCubed / CELS
- Director, Laboratory of Viral Immunity and Pathogenesis, iCubed
- Program Director, Center of Biomedical Research Excellence in translational infectious diseases immunology
- Program Director, Dengue Program Project Grant, an NIH-funded collaboration involving research in Thailand and Philippines.
Dr. Alan Rothman graduated from Boston University School of Medicine in 1983. He completed residency training in Internal Medicine and a clinical and research fellowship in Infectious Diseases, during which time he began his involvement in research on the immunology and pathogenesis of dengue and other viral infections, including influenza and hepatitis C. Dr. Rothman has long-standing collaborations with colleagues at the University of Massachusetts Medical School, Walter Reed Army Institute of Research, and internationally in Asia, Europe, and Latin America. He also has served on advisory committees for the National Institutes of Health and the World Health Organization.
Advisory Board Members
Arijit Bose, Ph.D., Professor and Chair, Department of Chemical Engineering, URI
Manon Cox, M.B.A., Ph.D., President and CEO, Protein Sciences Corporation
Cathy Curtin-Miller, Director of Finance & Administration, College of Nursing & Pharmacy, URI
Penny Dennehy, M.D., Hasbro Children’s Hospital
Leo Einck, Ph.D., Director, C.S.O., Sequella, Inc.
Loren Fast, Ph.D., Associate Professor of Medicine, Brown University
Robert Fleischmann, Ph.D., Program Director, Biological Infrastructure, NSF
Marta Gomez Chiarri, Ph.D., Professor, Animal and Veterinary Science, URI
Niall Howlett, Ph.D., Associate Professor, Department of Cell and Molecular Biology, URI
Bill Martin, COO EpiVax, Inc.
Polly Matzinger, Ph.D., Chief, T-Cell Tolerance, NIAID, NIH
Steven Opal, M.D., Professor of Medicine, Brown University
James Padbury, M.D., Chief of Pediatrics, Women & Infants, Professor, Brown University
Greg Paquette, Ph.D. Clinical Professor, Director of Biotech Program, URI
Joan Peckham, Ph.D., Professor and Chair of Computer Science and Statistics, URI
Bharat Ramratnam, M.D., COBRE CCRD Director, Principal Investigator, Brown University
Lenny Moise, Ph.D., Associate Research Professor
- Founding faculty member of iCubed
- Director of Vaccine Research, EpiVax, Inc.
- Research interests include immunological mechanisms of pathogenic and beneficial effects of H. pylori persistence; consequences of H. pylori eradication and immunological and technical solutions to advance epitope-based vaccine development
Dr. Moise received his Ph.D. from the Department of Molecular and Cellular Biology and Biochemistry at Brown University in 2002. His research in Dr. Edward Hawrot’s laboratory focused on structure-function relationships of snake neurotoxin interactions with the nicotinic acetylcholine receptor. Dr. Moise’s postdoctoral training at Brown University involved functional analysis of toxin binding sites engineered into toxin-insensitive ion channels. In 2005, he joined Dr. Anne De Groot’s laboratory at Brown University as an Instructor in Medicine in the Department of Medicine (Infectious Disease) to study T-cell epitope-driven vaccination and protein therapeutic immunogenicity. Dr. Moise has published over 40 original research papers.
Anuja Mathew, Ph.D., Associate Research Professor
- B.Sc. Women’s Christian College, Madras, India. 1989
- M.Sc. Christian Medical College, Vellore, India. 1992
- Ph.D. University of Massachusetts Medical School, Worcester, MA. 1999
- Post-Doctoral Training: Massachusetts General Hospital, 1999-2002
- Funding Portfolio Includes: NIH R21 $460,625 (2 years); P01 Flavavirus Project Leader $66,650 (annually for 5 years)
- Human immune responses to dengue virus infections
- Adaptive immune responses to dengue virus infections in humanized mice
Anuja Mathew, Ph.D., is a member of iCubed’s Laboratory of Viral Immunity and Pathogenesis and Research Associate Professor in the College of the Environment and Life Sciences at the University of Rhode Island. Dr. Mathew received her Ph.D. in 1999 from the University of Massachusetts Medical School. The title of her thesis was “Human T cell immune responses to Dengue Virus: CD8+CTL and Acute Immunosupression”. She was a post-doctoral fellow in the Center for Immunology and Infectious Diseases in the Laboratory of Dr. Andrew D Luster at the Massachusetts General Hospital from 1999-2003. She assessed chemokine expression to further understand lung-specific Th2 cell trafficking in an animal model of asthma in Dr. Luster’s laboratory. In 2004, she joined the Center for Infectious Disease and Vaccine Research at the University of Massachusetts Medical School as an Instructor of Medicine. Her research involved understanding immune responses to acute viral infections such as dengue virus, vaccinia virus and influenza virus. Dr. Mathew was an Assistant Professor in the Division of Infectious Diseases and Immunology in the Department of Medicine at the University of Massachusetts Medical School from 2008-2015. Through the use of basic immunology studies and novel humanized animal models, Dr. Mathew’s laboratory sought to further our understanding of adaptive immune responses to dengue virus infections.
In the Fall of 2015 Dr. Mathew moved to LVIP at the University of Rhode Island. The current research carried on in her laboratory at URI seeks to understand NK cell and B cell responses to dengue virus infections, develop biomarkers and provide insight to guide the development of an effective vaccine to dengue virus.
Barbara Lohman-Payne, Ph.D., Associate Research Professor
- BA, Biology, University of Denver
- PhD, Comparative Pathology, University of California, Davis
- Post-doctoral research fellowships: University of Massachusetts Medical Center with Dr. Raymond Welsh with a focus on immune down-regulation following of acute viral infections; University of Washington with Dr. Grace John-Stewart with a focus on translational immunological research
She was awarded a K01 grant through Fogarty International Center (NIH) for the study of infant immunity in HIV infection. She has 12 years of international experience in Kenya. Currently, her research interests include mother and infant immune responses to HIV-1 exposure and infection with a focus on prevention and vaccination and special interest in the impact of HIV exposure in pediatric immune development. She is also a Project Leader on the Centers for Biomedical Research Excellence grant $269,078 per year over 5 years.
Carey L. Medin, Ph.D., Assistant Research Professor
- Bachelor’s degree in Biochemistry and Molecular Biology, State University of New York at Albany
- PhD in 2005 in Immunology/Virology from the University of Massachusetts Medical Center
- Post-doctoral research fellowship at University of Massachusetts Medical Center with Dr. Kate Fitzgerald in innate immunity
Dr. Medin joined iCubed in 2011and brings with her 11 years experience in dengue viral research. Her lab’s research focus is centered on host-viral interactions that lead to changes in cellular organelles and innate immune activation during dengue viral infections. She is the recipient of FY14 Rhode Island STAC grant in the amount of $70,092. She is also a Project Leader on the Centers for Biomedical Research Excellence grant $263,140 per year over 5 years.
Anon Srikiatkhachorn, M.D., Associate Research Professor
- M.D. Chiang Mai University, Chiang Mai, Thailand
- Pediatric Residency, Michael Reese Hospital, Chicago, IL
- Immunology Fellow, St. Louis Children’s Hospital, Washington University School of Medicine, St. Louis, MO
- Postdoctoral Fellow, Allergy & Immunology, University of Virginia, Charlottesville, VA
Dr. Srikiatkhachorn’s research interests are in the area of immunopathogenesis of dengue hemorrhagic fever. He is a long-standing Co-Investigator on the Dengue Program Project grant, serving as the Clinical Laboratory Core Leader since 2003. He is based in Bangkok, Thailand, supervising clinical and laboratory activities supporting the field studies.
Awadalkareem Adam, Postdoctoral Fellow
- Postdoctoral Fellow
- D. in Virology from the University of Leipzig, Germany
- Sc. in Microbiology (Virology) from the University of Khartoum, Sudan
- Sc. in Biology (Microbiology) from the University of Africa, Sudan
After finishing his M.Sc. in Khartoum, Awad went to United Kingdom to get some experiences in virology at University of Nottingham. In 2010, he went to Germany for research training in molecular virology field at University of Leipzig, Institute of Virology. In 2011, he started his Ph.D., at University of Leipzig. During his Ph.D. study he visited Dr. Mathew’s Laboratory at University of Massachusetts Medical School as research scholar to learn dengue virus immunology.
After receiving his Ph.D., in Germany, Dr. Adam joined iCubed in April 2016. With his background in Virology and Immunology, and his previous experiences in the field of dengue viruses and other arboviruses, he is supporting Dr. Mathew research team in NK cell and B cell responses to dengue virus infections research projects.
Benjamin Gabriel, Postdoctoral Fellow
- Postdoctoral Fellow
- German diploma degree in Biology of the Johann Wolfgang Goethe University (Frankfurt, Germany)
- PhD performed at the Robert Koch Institute (Berlin, Germany)
- PhD degree obtained in 2014 in Immunology/Virology from the Freie Universität Berlin (Germany)
After finishing his PhD in Germany, Dr. Gabriel joined the iCubed team in November 2014. With his background in Virology and Immunology, and his previous works in the field of HIV/SIV, he is supporting the research team of Dr. Barbara Lohman-Payne. The main goal of the current project is the characterization of the T cell receptor repertoire of HIV exposed but uninfected (HEU) infants.
Kirk Haltaufderhyde, Postdoctoral Fellow
- Postdoctoral Fellow
- Ph.D. in Molecular Pharmacology & Physiology, Brown University
- B.S. in Biotechnology, York College/CUNY
After receiving his Ph.D., Dr. Haltaufderhyde joined iCubed in August 2016. He is supporting Dr. Rothman’s research team in dengue virus infections research projects.
Diane Lang, LVIP Lab Manager
Diane joined iCubed in April 2013 as a research associate in the Laboratory of Viral Immunity and Pathogenesis. She earned a bachelor’s of science degree in natural sciences from the University of Wisconsin-Madison in the College of Agriculture and Life Sciences. Diane has held positions in academia, biotechnology and most recently in the pharmaceutical industry. Her previous work focused on the fields of neuroscience and immunology working towards understanding and developing treatments for diseases such as Alzheimer’s, ALS, ADHD, bipolar disorder, Parkinson’s and arthritis. Diane brings to iCubed extensive and varied expertise in molecular and cell biology.
Darshika Udawatte, Graduate Student
· PhD student in Cell and Molecular Biology program
· Graduate research assistant at ICUBED
· MS in Biochemistry, University of Maine, USA
· BSc in Molecular Biology and Biotechnology, University of Peradeniya, Sri Lanka
Darshika joined Dr. Carey Medin’s lab as a PhD student in January 2016. She is interested in investigating cellular mechanisms modulated by dengue virus that may lead to viral pathogenesis in humans.
To improve human and animal health by applying the power of genomics and informatics to the design of better vaccines, diagnostics, and therapeutics.
We also seek to inspire and advance the role of women in science.
A world free of diseases caused by infection.
Developing new vaccines and immunotherapeutics, generating new knowledge by engaging in basic and applied research, and training the next generation of scientists.